| Name   | Location   | Market price   | Quest | Members Only | 
| Unicorn skin | Monster drop. | --- | Yes | Yes | 
| Unicorn stallion pouch | Player made (See Notes Section). | 2,694 gp | No | Yes | 
| Unicorn Stallion scroll (Healing Aura) | Obtained by transforming a Unicorn Stallion pouch on the obelisk. | 193 gp | No | Yes | 
| Unidentified liquid | Use a Vial on a barrel at the panning area of the Digsite, east of Varrock. | --- | Yes | Yes | 
| Unimaginable memory | Found on Erebus. | --- | Yes | Yes | 
| United Barrows necroplasm | Player Made (See Notes). | --- | No | Yes | 
| Unknown print | Made by using Flypaper with the with flour coated Criminal's dagger. | --- | Yes | Yes | 
| Unlit bug lantern | Bought at any Slayermaster. | 896 gp | No | Yes | 
| Unlit lantern | Obtained from the frozen lake found North East of the clearing. | --- | Yes | No | 
| Unlit torch | Respawns at the Fishing Platform, Tai Bwo Wannai general store, bought from Miltog's lamps at Dorgesh-Kaan for 6gp, bought from Aleck in Yanille, and pickpocketed from Cave goblins in Dorgesh-Kaan. | 298 gp | No | Yes | 
| Unlocked diary | Player made (See Notes Section). | --- | Yes | Yes | 
| Unmoulded soap | Player Made (See Notes Section). | --- | Yes | Yes | 
| Unpowered necromantic seal of the Cywir | Monster Drop. | --- | No | Yes | 
| Unpowered necromantic seal of the Dragon Riders | Monster Drop. | --- | No | Yes | 
| Unpowered necromantic seal of the Faceless | Monster Drop. | --- | No | Yes | 
| Unpowered necromantic seal of the Furies | Monster Drop. | --- | No | Yes | 
| Unpowered orb | Player made. | 262 gp | No | Yes | 
| Unpowered symbol (unholy Zamorak) | Player made. | 817 gp | No | Yes | 
| Unsanitary swill | Player made (See Notes Section). | --- | Yes | Yes | 
| Unstable effigy (uncharged) | Player Made (See Notes). | --- | No | Yes | 
| Unstable essence | Purchased from Wizard Rinsit in batches of 100 or 200 at a time, for Runespan Points. | 0 gp | No | No | 
| Unstamped letter | Given to you by one of the Examiners at the Exam Centre, southeast of Varrock. | --- | Yes | Yes | 
| Unstrung comp bow | Player made | 916 gp | No | Yes | 
| Unstrung emblem (unholy Zamorak) | Player made. Use a silver bar, with an unholy mould in your inventory, on a furnace to make this. It needs a ball of wool to become wearable. | 297 gp | No | Yes | 
| Unstrung lyre | Player made (See Notes Section). | --- | Yes | Yes | 
| Unstrung symbol (Saradomin) | Player made (See Notes Section) and Silver merchant in East Ardougne. | 1,199 gp | No | No | 
| Unsullied sigil | Made by combining 1,000 vital sparks. | 0 gp | No | Yes | 
| Untempered masterwork armour piece | Player Made (See Notes). | --- | No | Yes | 
| Unusual armour | Searching bushes outside of Watchtower, north Yanille. | --- | Yes | Yes | 
| Unusual fish | Given to you by the Fisherman, north of Rellekka's market, in exchange for the Sea fishing map. | --- | Yes | Yes | 
| Upgraded bone blowpipe | Player Made (See Notes). | 3.0m gp | No | Yes | 
| Uraeus (apep's axe) | Obtained after the Diamond in the Rough quest by slicing Dung kalphites in the Kalphite Nursery. | --- | Yes | Yes | 
| Urist's talisman | Pickpocketed from Urist Loric in Varrock. | --- | No | Yes | 
| Urn enhancer | Player made (See Notes Section). | --- | No | Yes | 
| Used folder | Player made (See Notes Section). | --- | Yes | Yes | 
| Useless ration boxes | Pyramid in the Missing My Mummy quest. | --- | Yes | Yes | 
| Ushabti (Empty) | Given by Faiza in the Sunken Pyramid; Bought from Slayer Masters | --- | No | Yes | 
| Utuku branches | Can be obtained from a spinebeam tree, as a monster drop, or purchased from the Smuggler. | 0 gp | No | No | 
| Utuku longbow | Player made (See Notes Section); monster drop. | 0 gp | No | No | 
| Utuku longbow (u) | Player made (See Notes Section). | 0 gp | No | Yes | 
| Utuku shortbow | Monster drop; player made (See Notes Section). | 0 gp | No | No | 
| Utuku shortbow (u) | Player made (See Notes Section). | 0 gp | No | Yes | 
| Utuku staff | Monster drop; player made (See Notes Section). | 0 gp | No | No | 
| Utuku trap | Player made (See Notes Section). | 0 gp | No | Yes | 
| Utuku wand | Player made (See Notes Section); Monster drop. | 0 gp | No | No | 
| V's journal | Found by searching V's belongings inside the cave. | --- | Yes | Yes | 
| Valentine heart | Found while skilling or killing monsters, it was also a reward from the discontinued Squeal of Fortune. | 0 gp | No | No | 
| Valentine's note | Obtained from a Jagex Moderator during an event. | --- | No | No | 
| Valentine's Petals | On Treasure Hunter or via skilling. | --- | No | No | 
| Valerian potion (unf) | Player made. (See other information) | 0 gp | No | Yes | 
| Valerian seed | Monster drop; bought from the smuggler in the dungeons of Daemonheim. | 0 gp | No | Yes | 
| Valve inner wheel | Found on a box in the cave system under Ashdale during A Shadow Over Ashdale. | --- | No | No | 
| Valve outer wheel | Found on a box in the cave system under Ashdale during A Shadow Over Ashdale. | --- | No | No | 
| Valve wheel | Searching crates on the first floor of the Tower of Life. | --- | Yes | Yes | 
| Valve wheel (A Shadow Over Ashdale) | Player made (See Notes Section). | --- | No | No | 
| Vamplushie | In the Meiyerditch mine, the plushie is found on the western-most minecart. | --- | Yes | Yes | 
| Vampyre bat pouch | Player made (See Notes Section). | 1,450 gp | No | Yes | 
| Vampyre Bat scroll (Vampyre Touch) | Using a Vampyre bat pouch on an obelisk. | 102 gp | No | Yes | 
| Vampyre dust | Kill vampyres east of Canifis and Draynor Manor during the Vampyre Slayer Quest. 
 Vampyre dust is also a possible loot from Spirit implings.
 | 1,912 gp | No | No | 
| Vampyre fangs | Monster drop. | --- | No | Yes | 
| Vampyre hunter amulet | Bought for 500 feral vampyre fangs during a Treasure Hunter Promotion. | --- | No | No | 
| Vanescula's offer | Given to the player by Vanescula Drakan. | --- | Yes | Yes | 
| Vanguard body | Reward bought from Stanley Limelight or the Minigame Spotlight Podium. | --- | No | Yes | 
| Vanguard boots | Reward bought from Stanley Limelight or the Minigame Spotlight Podium. | --- | No | Yes | 
| Vanguard gloves | Reward bought from Stanley Limelight or the Minigame Spotlight Podium. | --- | No | Yes | 
| Vanguard helm | Reward bought from Stanley Limelight or the Minigame Spotlight Podium. | --- | No | Yes | 
| Vanguard legs | Reward bought from Stanley Limelight or the Minigame Spotlight Podium. | --- | No | Yes | 
| Vanilla cheesecake | Player Made (See Notes). | 307 gp | No | Yes | 
| Vanilla Cow | Result of checking a Vanilla cow (unchecked); Result of breeding cows at Player-Owned Farms. | 0 gp | No | Yes | 
| Vanilla cow (unchecked) | Chance to obtain from Adam Antite or Callia. | 121.4k gp | No | Yes | 
| Vanilla cream cheese | Player Made (See Notes). | 100 gp | No | Yes | 
| Vanilla fudge log | This item was a reward from the discontinued Squeal of Fortune. | --- | No | No | 
| Vanilla hair head token | Randomly obtained while participating in any of the activities at the Summer Beach Party event, including defeating Clawdia; Purchased from Flo. | 255.7k gp | No | No | 
| Vanilla milk | Harvesting produce from Vanilla cows at the Manor farm. | 3,964 gp | No | No | 
| Vanilla pod | Search the Vanilla Trees in the Kharazi Jungle, south of Shilo Village . | --- | Yes | Yes |