| Name   | Location   | Market price   | Quest | Members Only | 
| Dramen staff | Player made (See Notes Section). | --- | Yes | Yes | 
| Draynor skull | Dig the grave at the back of Draynor Manor. | --- | Yes | Yes | 
| Dreadfowl pouch | Player made (See Notes). | 447 gp | No | No | 
| Dreadfowl scroll (Dreadfowl Strike) | Player made. | 39 gp | No | Yes | 
| Dreadnip | Obtained from the Strange face after 450 bosses have been killed within the Dominion Tower, and the player has spectated on one match. | --- | No | Yes | 
| Dream potion | Player made (See Notes Section). | --- | Yes | Yes | 
| Dreamy lamp | Reward after completing Dream Mentor. | --- | No | Yes | 
| Dried chillies | Obtained randomly while skilling; random amount given from opening a Food bag or Large food bag. | 0 gp | No | Yes | 
| Dried thistle | Player made (See Notes Section). | --- | Yes | Yes | 
| Driftwood | Found in the cave during Tale of the Muspah. | --- | Yes | Yes | 
| Driftwood (hunting) | Penguin Hunting Area (See Notes Section). | --- | No | Yes | 
| Driftwood (Mazcab) | Beach of Kanatah. | --- | No | Yes | 
| Driftwood (The Arc) | Monster drop; Purchased from Zhuka or Wan Pian when in stock; Found on Uncharted Isles. | --- | No | Yes | 
| Drogokishuun hook sword | Unknown, please submit. | --- | No | Yes | 
| Drogokishuun hook sword (damaged) | Obtained by excavating Warforge weapon rack; Obtained by completing Warforge Dig Site Site Research; Obtained by opening Ancient caskets. | --- | No | Yes | 
| Dromoleather body | Monster drop; player made (See Notes Section). | 0 gp | No | No | 
| Dromoleather boots | Player made (See Notes Section); monster drop. | 0 gp | No | No | 
| Dromoleather chaps | Player made (See Notes Section); monster drop. | 0 gp | No | No | 
| Dromoleather coif | Monster drop; player made (See Notes Section). | 0 gp | No | No | 
| Dromoleather shield | Player made (See Notes Section); Monster drop. | 0 gp | No | No | 
| Dromoleather torn bag | Monster drop while Dungeoneering. | 0 gp | No | No | 
| Dromoleather vambraces | Monster drop; player made (See Notes Section). | 0 gp | No | No | 
| Dromomastyx hide | Dropped by a dromomastyx; obtained by hunting a dromomastyx; monster drop; bought from the smuggler in the start room while training Dungeoneering. | 0 gp | No | No | 
| Druid engram | Found inside the Druid's circle in Taverley. | --- | No | Yes | 
| Druid engram (charged) | Player Made (See Notes). | --- | No | Yes | 
| Druid pouch | Found inside The Nature Spirit's Grotto. | --- | Yes | Yes | 
| Druid robe (bottom) | Dropped by Druids in Taverley. | 226 gp | No | No | 
| Druid's robe (top) | Monster drop. | 253 gp | No | No | 
| Druidic mage bottom (100) | Bought from Reggie at the Fist of Guthix lobby. | --- | No | No | 
| Druidic mage bottom 0 | Fist of Guthix shop. | 83.8k gp | No | No | 
| Druidic mage hood (100) | Bought from Reggie at the Fist of Guthix lobby. | --- | No | No | 
| Druidic mage hood 0 | Fist of Guthix Mini-game store. | 8,694 gp | Yes | No | 
| Druidic mage top (100) | Bought from Reggie at the Fist of Guthix lobby. | --- | No | No | 
| Druidic mage top 0 | Fist of Guthix shop. | 107.5k gp | No | No | 
| Druidic spell | Given to you by Filliman Tarlock. | --- | Yes | Yes | 
| Drunk dragon | Player Made (See Notes); Purchased from Gabooty. | 28.6k gp | No | Yes | 
| Drunk parrot | Caught by using Alco-chunks on the aviary hatch in the Ardougne Zoo. | --- | Yes | Yes | 
| Dry logs | Cut from the wall gap inside the ferret challenge room. | 0 gp | No | Yes | 
| Dry seaweed | Player Made (See Notes). | --- | Yes | Yes | 
| Dry sticks | Fishing Platform. | --- | Yes | Yes | 
| Drygore longsword | Monster drop; Player made (See Notes Section). | 28.0m gp | No | Yes | 
| Drygore longsword shard | Monster drop. | 119.3k gp | No | Yes | 
| Drygore mace | Monster drop; Player made (See Notes Section). | 19.4m gp | No | Yes | 
| Drygore mace shard | Monster drop. | 57.6k gp | No | Yes | 
| Drygore rapier | Monster drop; Player made (See Notes Section). | 20.0m gp | No | Yes | 
| Drygore rapier shard | Monster drop. | 100.9k gp | No | Yes | 
| Duck ring token | Found while skilling on the beach during the Summer Beach Party | 604.7k gp | No | No | 
| Duellist's cap (Tier 1) | Obtain for free from Estocada found at the Al Kharid Duel Arena entrance. | --- | No | No | 
| Duellist's cap (Tier 2) | Obtain for free from Estocada found at the Al Kharid Duel Arena entrance. | --- | No | No | 
| Duellist's cap (Tier 3) | Obtain for free from Estocada found at the Al Kharid Duel Arena entrance. | --- | No | No | 
| Dungeoneering cape | Purchased from Thok, Master of Dungeoneering. | --- | No | Yes | 
| Dungeoneering cape (t) | Purchased from Thok, Master of Dungeoneering. | --- | No | Yes | 
| Dungeoneering hood | Received from Thok, Master of Dungeoneering when buying a Dungeoneering cape. | --- | No | Yes | 
| Dungeoneering lock melter | Player Made (See Notes). | --- | No | Yes | 
| Dungeoneering master cape | Purchased from Thok, Master of Dungeoneering. | --- | No | Yes | 
| Dungeoneering party simulator. | Player Made (See Notes). | --- | No | Yes | 
| Dungeoneering tokens (10) | Possible loot from pickpocketing Meilyr workers in Prifddinas. | --- | No | Yes | 
| Dungeoneering tokens (100) | Pickpocketed from Meilyr workers in Prifddinas. | --- | No | Yes | 
| Dusk eel | Player made (See Notes Section); Monster drop. | --- | No | No | 
| Dusk eel & edicap potato | Player made. | 0 gp | No | Yes | 
| Dusk eel & gissel potato | Player made. | 0 gp | No | Yes | 
| Dusk eel potato | Player made. | 0 gp | No | Yes | 
| Duskweed | Throughout dungeons on plants or monster drop; Bought from the Smuggler in the start room of dungeons in Daemonheim. | 0 gp | No | Yes | 
| Duskweed cloth | Player made (See notes section). | 0 gp | No | Yes | 
| Duskweed gloves | Player made (See Notes Section); monster drop. | 0 gp | No | Yes | 
| Duskweed hood | Player made (See Notes Section); monster drop. | 0 gp | No | Yes | 
| Duskweed orb | Player made (See Notes Section); Monster drop. | 0 gp | No | No | 
| Duskweed robe bottom | Player made (see Notes section); monster drop. | 0 gp | No | Yes | 
| Duskweed robe top | Player made (See Notes Section) or monster drop. | 0 gp | No | Yes | 
| Duskweed shield | Player made (See Notes Section); Monster drop. | 0 gp | No | Yes | 
| Duskweed shoes | Player made (See Notes Section); monster drop. | 0 gp | No | Yes | 
| Dust of Armadyl | Player made (See Notes Section). | 6,825 gp | No | Yes | 
| Dust rune | Monster drop, or player made (see notes). | 3,239 gp | No | Yes | 
| Dusty key | Bought from Siegfried Erkle in the Legends' Guild. Obtained from Velrak the explorer. | --- | No | Yes | 
| Dusty scroll | Player made (See Notes Section). | --- | Yes | Yes |