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| N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 
| Name   | Location   | Market price   | Quest | Members Only | 
| Sign of respite II | Player made (See Notes Section). | 2,708 gp | No | Yes | 
| Sign of respite I | Player made (See Notes Section). | 1,920 gp | No | Yes | 
| Sign of life | Player made (See Notes Section). | 9,372 gp | No | Yes | 
| Sign of item protection | Player made (See Notes Section). | 4,361 gp | No | Yes | 
| Sign of death | Player made (See Notes Section). | 26.1k gp | No | Yes | 
| Sigil piece (Zaros) | Obtained from killing Vindicta inside The Heart of Gielnor. | --- | No | Yes | 
| Sigil piece (Zamorak) | Obtained from killing The Twin Furies inside The Heart of Gielnor. | --- | No | Yes | 
| Sigil piece (Sliske) | Obtained from killing Gregorovic inside The Heart of Gielnor. | --- | No | Yes | 
| Sigil piece (Seren) | Obtained from killing Helwyr inside The Heart of Gielnor. | --- | No | Yes | 
| Sigil of slaying | Purchased from Abyssal Knight Quartermaster. | --- | No | Yes | 
| Sifu | This pet is found whilst training while using Attack. | --- | No | Yes | 
| Sieve | Given to you by Elena in Lletya, or the Chemist in Rimmington. | --- | Yes | Yes | 
| Sickle mould | Bought from Dommik in Al Kharid and Rasolo west of the Fishing Guild. | 1,177 gp | No | Yes | 
| Shrunk ogleroot | Monster drop; inside a secret compartment of a piano in the witch's house in Taverley. | 106 gp | Yes | Yes | 
| Shrivelled dagannoth claw | Monster drop. | --- | No | Yes | 
| Shrinking recipe | Inside a secret compartment of a piano in the witch's house in Taverley. | --- | Yes | Yes | 
| Shrink-me-quick | Player made (See Notes Section). | --- | Yes | Yes | 
| Shrimps | Player made (See Notes Section). | 340 gp | No | No | 
| Shredflesh's tooth | Obtained from pulling the tooth from General Shredflesh's mouth. | --- | Yes | Yes | 
| Shovel sword override token | Randomly obtained while participating in any of the activities at the Summer Beach Party event, including defeating Clawdia; Purchased from Sheldon. | 644.8k gp | No | No | 
| Shoulder bone | Dropped by any giants only during the Fur 'n' Seek quest. | --- | Yes | Yes | 
| Shorts (yellow) | Bought from Agmundi in Keldagrim. | 1,779 gp | No | Yes | 
| Shorts (brown) | Bought from Vermundi in Keldagrim. | 2,212 gp | No | Yes | 
| Shorts (blue) | Bought from Agmundi in Keldagrim. | 4,379 gp | No | Yes | 
| Shortfin & gissel potato | Player made. | 0 gp | No | Yes | 
| Shortfin & edicap potato | Player made. | 0 gp | No | Yes | 
| Shortcut key | Reward for the Darkness of Hallowvale quest. | --- | Yes | Yes | 
| Shortbow (u) | Player Made. | 1,274 gp | No | No | 
| Shortbow | Repsawns northwest of the right side of the bridge over the River Elid. Upstairs in a house in Taverly. Player made (See Notes); Bought from Bow and Arrow salesman in the Ranging Guild; Possible monster drop. | 3,900 gp | No | No | 
| Short-finned eel | Player made (See Notes Section) or Monster drop. | --- | No | No | 
| Short-fin eel potato | Player made (See Notes Section). | 0 gp | No | Yes | 
| Short vine | Player made using a knife on swamp tree (bop event in Temple Trekking). | --- | No | Yes | 
| Short green guy | Player Made (See Notes). | 2,591 gp | No | Yes | 
| Shopping list | Given by King Roald during the thanksgiving 2011 event. | --- | Yes | Yes | 
| Shoes | Respawns in Awusah the Mayor's house. | --- | Yes | Yes | 
| Shoe box | Player made using 2 Planks and 2 Nails on a workbench. | 9 gp | Yes | Yes | 
| Shock absorber | Purchased from Dodgy Derek. | --- | No | Yes | 
| Shirt (yellow) | Bought from Agmundi in Keldagrim. | 1,441 gp | No | Yes | 
| Shirt (pink) | Bought from Agmundi in Keldagrim. | 991 gp | No | Yes | 
| Shirt (brown) | Bought from Vermundi in Keldagrim. | 1,019 gp | No | Yes | 
| Shipping order | Obtained from Rufus. | --- | Yes | Yes | 
| Ship ticket | Sereval in Shilo Village. | 0 gp | No | Yes | 
| Ship repair kit | Obtained from Rosie. | --- | No | Yes | 
| Ship figurehead | Possible reward from opening Prawn balls. | 77 gp | No | Yes | 
| Shiny XP lamp | Talk to Diango in Draynor village. | --- | No | No | 
| Shiny tortle shell bowl | Player Made (See Notes). | --- | No | Yes | 
| Shiny tiara | Obtained from Safecracking. | --- | No | Yes | 
| Shiny shell chippings | Obtained from Ornate tortles on Uncharted Islands within the Arc. | --- | No | Yes | 
| Shiny ring | Obtained from Safecracking. | --- | No | Yes | 
| Shiny necklace | Obtained from Safecracking. | --- | No | Yes | 
| Shiny key | In the Temple of Ikov dungeon, past the Lesser Demons. | --- | Yes | Yes | 
| Shiny gem | Obtained from Safecracking. | --- | No | Yes | 
| Shiny columbarium key | A reward for burning a Vyre corpse with Magic pyre logs or Elder pyre logs on a funeral pyre in the Columbarium in Paterdomus Temple, located west of Canifis. | --- | No | Yes | 
| Shiny bracelet | Obtained from Safecracking. | --- | No | Yes | 
| Shiny amulet | Obtained from Safecracking. | --- | No | Yes | 
| Shining alchemist's amulet | Obtained by combining less than 10 alchemist's amulet fragments and transforming them into an amulet. | --- | No | Yes | 
| Shinigami orokami mask | From looting a Murderous orokami or looting a Murderous orokami jar. | 553.9k gp | No | Yes | 
| Shimmering shell | Found by searching the net after a trawler fishing voyage. | 0 gp | No | Yes | 
| Shimmering honeycomb | Player Made (See Notes). | 355.7k gp | No | Yes | 
| Shimmering feather | Plucked from the Strange bird on the Southern peninsula of Anachronia. | --- | Yes | Yes | 
| Shifter charm | Bought from the Void Outpost Knight's for 2 points each. | --- | No | Yes | 
| Shieldbow sight | Purchased from the Rewards trader. | --- | No | No | 
| Shieldbow (u) | Player Made (See Notes Section). | 928 gp | No | No | 
| Shieldbow | Player made (See Notes); Bought from Bow and Arrow salesman in the Ranging Guild; Possible monster drop. | 3,847 gp | No | No | 
| Shield right half | Bought from Siegfried Erkle in the Legends' Guild. | 794.1k gp | No | Yes | 
| Shield of Arrav (Dimension of Disaster) | Obtained by combining both broken halves of the shield together during the quest Dimension of Disaster. | --- | No | Yes | 
| Shield left half (dragon square) | Monster drop. | 69.4k gp | Yes | Yes | 
| Shield fragment | Player made (See Notes Section). | --- | Yes | Yes | 
| Shengo seed | Possible reward from capturing jadinkos in Herblore Habitat. | --- | No | Yes | 
| Shengo potion (unf) | Player made (See Notes Section). | --- | No | Yes | 
| Shell-rat | Player Made (See Notes). | --- | Yes | Yes | 
| Shell chippings | Collected from Tortles on Whale's Maw or Uncharted Islands. | --- | No | Yes | 
| Sheepdog puppy | Purchased from Pet Shops. | --- | No | No | 
| Sheepdog | Obtained from growing a Sheepdog puppy. | --- | No | Yes | 
| Sheep mask | Possible reward from a Reward casket (medium). | 1.4m gp | No | No | 



 
                 
                 
                 
                
            